Skip to main content

Cheap bus tickets from Des Moines, IA to San Antonio, TX

Person using FlixBus app

Get ready!

Bus arriving in 3 mins.

Scan to download the App
Get the app and travel with ease of mind

Get live updates with push notifications and track your trip in real time. All of your travel details in one place.

android store img app store img

Connecting you to the world

Endless possibilities. Discover over 6,800 destinations across more than 40 countries.

Comfort on the go

Kick back with free Wi-Fi, power outlets, and extra leg space. That's what modern buses are all about.

Choose, book, travel

From your screen to your seat in seconds. You do the booking, we'll take care of the rest.

Planet-smart travel

Drop the car, travel with us. Increase your mileage and reduce your carbon footprint.

What to expect of your trip

Fast, easy, and affordable options from Des Moines, IA to San Antonio, TX
lp_redesign_trip_overview_usps_safe_payment_label
Safe Payment
Use Paypal, Google Pay, Visa & International cards
lp_redesign_trip_overview_usps_easy_label
Easy to buy
Get your tickets online, in our App, or in a Flixshop
lp_redesign_trip_overview_usps_customer_care_label
Customer care
Effortless support from booking to travel

On this page

Bus stations and stops in Des Moines, IA

Please note: your ticket will contain the most up-to-date address information.

Discover all destinations

Frequently asked questions

No, you don't need to print your ticket if you purchased it online or via the app. Simply show the driver the QR code that you received via email or that is stored in the app and you're ready to travel from Des Moines to San Antonio. It's that easy!
You can get from Des Moines to San Antonio for as little as 144,55 €. Take advantage of our best deals on FlixBus tickets by traveling off-peak and during the week. You can buy your ticket from Des Moines to San Antonio most easily on this website or in the app.
When traveling from Des Moines to San Antonio, you can track your bus location on our Real-Time Bus Tracker. Just select the relevant bus stop and check the time of arrival. Find out where your bus is and check if there are delays on the route.
We offer several payment methods for purchasing your ticket from Des Moines to San Antonio securely. You can choose among card payment, PayPal, Google Pay and many more. Once in the payment section, you will be able to see all the available options and pick your preferred one. If you are having difficulties with payment, check out our help page about payments. If you buy your bus ticket onboard or at a sales point you are also given the option to pay cash.
Passengers traveling from Des Moines to San Antonio can bring one checked luggage and one piece of hand luggage for free. If you want to carry additional or special luggage, you can check all the options available on this page.
The price of a children's bus ticket from Des Moines to San Antonio depends on the age of the child and the time of booking. Children under the age of 15 receive a discount on the regular adult fare. At the time of booking, we calculate the cheapest price for you from all available rates and discounts. If the discounted price is lower than the child fare, the selected passengers pay the same price. Please, make sure you check our child travel and seat policy. Strollers and foldable pushchairs (width + length + height = max 240 cm) can be transported in the luggage compartment of the bus free of charge.
Yes, all FlixBus buses from Des Moines to San Antonio are equipped for passengers with reduced mobility. We strive to make our buses as comfortable and accessible as possible for people with disabilities and limited mobility. Service animals are allowed on board all FlixBus buses traveling from Des Moines to San Antonio. The transportation of wheelchairs, foldable wheelchairs, walking aid and other assistive mobility devices is free of charge.
FlixBus buses traveling from Des Moines to San Antonio offer extra legroom, private outlets, and restrooms. Most buses also provide free Wi-Fi.
The earliest FlixBus ride from Des Moines to San Antonio departs at 04:20.
The latest FlixBus ride from Des Moines to San Antonio departs at 23:45.
There are 2 bus stations in Des Moines; Des Moines, Des Moines (Subway). You can find the location of the stations on the map on this page.
There are 2 bus stations in San Antonio; San Antonio Bus Station, San Antonio Pearl District. You can find the location of the stations on the map on this page.
Yes, night trip options are available from Des Moines to San Antonio. Check out the route's schedule and choose the best option to suit your plans!
With FlixBus, you can conveniently reach 62 destinations from San Antonio, including Houston, Austin, Laredo.
Traveling by bus from Des Moines to San Antonio is one of the most environmentally-friendly options available as it reduces traffic associated emissions, and passengers can offset their carbon emissions when they travel with FlixBus by clicking the CO₂ compensation box when booking their ticket.

Looking for bus tickets from Des Moines to San Antonio?

Look no further, we’ve got all the details you need to plan your bus trip! The journey Des Moines to San Antonio takes as little as 23 hours 5 minutes and can cost as little as 144,55 €. The first bus leaves at 04:20 and the last bus leaves at 23:45. FlixBus runs 3 rides each day between Des Moines and San Antonio and when travelling with FlixBus, you can expect free Wifi, power sockets and a guaranteed seat for your journey.

Onboard services are subject to availability