Skip to main content

Cheap bus tickets from Florence, SC to Knoxville, TN

from 54,99 €

Health and Safety

Keep yourself and others safe while traveling with us.
Learn more

Comfort on board

Our buses are equipped with large and comfortable seats, a toilet, Wi-Fi and power outlets.
Our onboard service

Largest bus network in Europe

Choose from over 3,000 travel destinations in 40+ countries and discover Europe with FlixBus.
Our route network

Travel environmentally-friendly

Our efficient coaches are proven to have an excellent carbon footprint per driven passenger-kilometer.
Bus travel and environment

On this page

Bus stations and stops in Florence, SC

Please note: your ticket will contain the most up-to-date address information.

Discover all destinations

Frequently asked questions

With FlixBus, you can conveniently reach 23 destinations from Knoxville, including Nashville, Atlanta, Memphis.
Yes, night trip options are available from Florence to Knoxville. Check out the route's schedule and choose the best option to suit your plans!
You can get from Florence to Knoxville for as little as 54,99 €. Take advantage of our best deals on FlixBus tickets by traveling off-peak and during the week. You can buy your ticket from Florence to Knoxville most easily on this website or in the app.
When traveling from Florence to Knoxville, you can track your bus location on our Real-Time Bus Tracker. Just select the relevant bus stop and check the time of arrival. Find out where your bus is and check if there are delays on the route.
We offer several payment methods for purchasing your ticket from Florence to Knoxville securely. You can choose among card payment, PayPal, Google Pay and many more. Once in the payment section, you will be able to see all the available options and pick your preferred one. If you are having difficulties with payment, check out our help page about payments. If you buy your bus ticket onboard or at a sales point you are also given the option to pay cash.
Passengers traveling from Florence to Knoxville can bring one checked luggage and one piece of hand luggage for free. If you want to carry additional or special luggage, you can check all the options available on this page.
The price of a children's bus ticket from Florence to Knoxville depends on the age of the child and the time of booking. Children under the age of 15 receive a discount on the regular adult fare. At the time of booking, we calculate the cheapest price for you from all available rates and discounts. If the discounted price is lower than the child fare, the selected passengers pay the same price. Please, make sure you check our child travel and seat policy. Strollers and foldable pushchairs (width + length + height = max 240 cm) can be transported in the luggage compartment of the bus free of charge.
Yes, all FlixBus buses from Florence to Knoxville are equipped for passengers with reduced mobility. We strive to make our buses as comfortable and accessible as possible for people with disabilities and limited mobility. Service animals are allowed on board all FlixBus buses traveling from Florence to Knoxville. The transportation of wheelchairs, foldable wheelchairs, walking aid and other assistive mobility devices is free of charge.
Traveling by bus from Florence to Knoxville is one of the most environmentally-friendly options available as it reduces traffic associated emissions, and passengers can offset their carbon emissions when they travel with FlixBus by clicking the CO₂ compensation box when booking their ticket.
FlixBus buses traveling from Florence to Knoxville offer extra legroom, private outlets, and restrooms. Most buses also provide free Wi-Fi.
The earliest FlixBus ride from Florence to Knoxville departs at 08:05.
The latest FlixBus ride from Florence to Knoxville departs at 23:59.
There are 2 bus stations in Florence; Florence (SC), Florence Bus Station. You can find the location of the stations on the map on this page.
No, you don't need to print your ticket if you purchased it online or via the app. Simply show the driver the QR code that you received via email or that is stored in the app and you're ready to travel from Florence to Knoxville. It's that easy!
There is one bus station in Knoxville; Knoxville Area Transit Bus Stop. You can find its location on the map on his page.

Looking for bus tickets from Florence to Knoxville?

Look no further, we’ve got all the details you need to plan your bus trip! The journey Florence to Knoxville takes as little as 14 hours 15 minutes and can cost as little as 54,99 €. The first bus leaves at 08:05 and the last bus leaves at 23:59. FlixBus runs daily rides between Florence and Knoxville and when travelling with FlixBus, you can expect free Wifi, power sockets and a guaranteed seat for your journey.

Onboard services are subject to availability