Skip to main content

Cheap bus tickets from Florence, SC to San Francisco, CA

from 221,98 €

Connecting you to the world

Endless possibilities. Discover over 8,000 destinations across more than 40 countries.

Comfort on the go

Kick back with free Wi-Fi, power outlets, and extra leg space. That's what modern buses are all about.

Choose, book, travel

From your screen to your seat in seconds. You do the booking, we'll take care of the rest.

Go together

Why adding another car on the road when you can choose collective travel instead?

What to expect of your trip

Fast, easy, and affordable options from Florence, SC to San Francisco, CA

Avg. trip duration

72 hr 33 mins

Card icon

Avg. distance

5049 km

Card icon

Cheapest trip

From 221,98 €

Card icon

2

Avg. trips a day

Card icon

Digital ticket & Live tracking

Discover the FlixBus app

Book trips
Your tickets
Track your trip
Always in-the-know
Get it on Google Play Download on the App Store
FlixBus app on phone

Scan to download the App

Trusted by 500+ million passengers

On this page

Bus stations and stops in Florence, SC

Please note: your ticket will contain the most up-to-date address information.
Best service on board
Available options you can find for a more comfortable trip:
wifi
Free WiFi
Stay connected throughout your journey
socket
Power Outlets
Keep your devices charged on the go
seat
Comfortable seats
Relax with extra legroom and reclining seats
luggage
Luggage storage
Space to safely stow your belongings
toilet
Toilets
Conveniently available on every FlixBus
First time travelling with us?
More on our service
Amenities Hero Image

Onboard services are subject to availability

Where to next?
Discover our travel map with over 8000 destinations worldwide.
Explore the map
Vehicle passing through a city

Digital ticket & Live tracking

Discover the FlixBus app

Book trips
Your tickets
Track your trip
Always in-the-know
Get it on Google Play Download on the App Store
FlixBus app on phone

Scan to download the App

Trusted by 500+ million passengers

Frequently asked questions

Yes, night trip options are available from Florence to San Francisco. Check out the route's schedule and choose the best option to suit your plans!
With FlixBus, you can conveniently reach 25 destinations from San Francisco, including Los Angeles, Sacramento, Reno/Sparks.
When traveling from Florence to San Francisco, you can track your bus location on our Real-Time Bus Tracker. Just select the relevant bus stop and check the time of arrival. Find out where your bus is and check if there are delays on the route.
We offer several payment methods for purchasing your ticket from Florence to San Francisco securely. You can choose among card payment, PayPal, Google Pay and many more. Once in the payment section, you will be able to see all the available options and pick your preferred one. If you are having difficulties with payment, check out our help page about payments. If you buy your bus ticket onboard or at a sales point you are also given the option to pay cash.
Passengers traveling from Florence to San Francisco can bring one checked luggage and one piece of hand luggage for free. If you want to carry additional or special luggage, you can check all the options available on this page.
The price of a children's bus ticket from Florence to San Francisco depends on the age of the child and the time of booking. Children under the age of 15 receive a discount on the regular adult fare. At the time of booking, we calculate the cheapest price for you from all available rates and discounts. If the discounted price is lower than the child fare, the selected passengers pay the same price. Please, make sure you check our child travel and seat policy. Strollers and foldable pushchairs (width + length + height = max 240 cm) can be transported in the luggage compartment of the bus free of charge.
Yes, all FlixBus buses from Florence to San Francisco are equipped for passengers with reduced mobility. We strive to make our buses as comfortable and accessible as possible for people with disabilities and limited mobility. Service animals are allowed on board all FlixBus buses traveling from Florence to San Francisco. The transportation of wheelchairs, foldable wheelchairs, walking aid and other assistive mobility devices is free of charge.
Traveling by bus from Florence to San Francisco is one of the most environmentally-friendly options available as it reduces traffic associated emissions, and passengers can offset their carbon emissions when they travel with FlixBus by clicking the CO₂ compensation box when booking their ticket.
FlixBus buses traveling from Florence to San Francisco offer extra legroom, private outlets, and restrooms. Most buses also provide free Wi-Fi.
The earliest FlixBus ride from Florence to San Francisco departs at 00:05.
The latest FlixBus ride from Florence to San Francisco departs at 16:10.
There are 2 bus stations in Florence; Florence (SC), Florence Bus Station. You can find the location of the stations on the map on this page.
There are 2 bus stations in San Francisco; San Francisco (5th/Townsend), San Francisco Bus Station. You can find the location of the stations on the map on this page.
No, you don't need to print your ticket if you purchased it online or via the app. Simply show the driver the QR code that you received via email or that is stored in the app and you're ready to travel from Florence to San Francisco. It's that easy!

Looking for bus tickets from Florence to San Francisco?